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Operational Medicine 2001
Probenecid (Benemid)

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Category:

  • Antigout agent; uricosuric

Description:

  • Increases urinary excretion of uric acid; inhibits tubular penicillin and most cephalosporin secretion (increasing plasma levels)

Indications:

  • Hyperuricemia associated with gout and gouty arthritis

  • Elevation of plasma penicillin concentrations

  • Elevation of plasma cephalosporin concentrations

Contraindications:

  • Children under age 2

  • Blood dyscrasias

  • Uric acid kidney stones

  • Moderate to severe renal impairment (CrCl <10ml/min)

Precautions:

  • Pregnancy category B

  • History of peptic ulcer

Adverse Reactions (Side Effects):

  • Central Nervous System: dizziness, headache

  • Gastrointestinal: anorexia, nausea, sore gums, vomiting

  • Genitourinary: costovertebral pain, hematuria,mephrotic syndrome, renal colic, uric acid stones, urinary frequency

  • Hematological: Anemia, aplastic anemia, hemolytic anemia

  • Flushing, rash, hypersensitivity reactions  

Dosage:

Oral tablets

  •  Adult:

    • Hyperuricemia:

      • 250mg twice daily for 7 days; increase to 500mg twice daily; increase every 4 weeks as needed to a maximum of 2-3 grams daily.

    • Penicillin or cephalosporin therapy:

      • 500mg four times daily

  • Children: 

    • Penicillin or cepharlosporin therapy:

      • 25mg/kg/day initially; 40mg/kg/day divided four times daily

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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