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Operational Medicine 2001
Primaquine

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Category:

  • Antimalarial

Description:

  • 8-aminoquinoline, related to 4- aminoquinoline

Indications:

  • · P. vivax malaria treatment

Contraindications:

  • Concomitant administration of quinacrine

  • Concomitant administration of poitentially hemolytic or bone marrow suppressive medications

Precautions:

  • Pregnancy category C

  • Patients suffering from P. vivax malaria should receive chloroquine which quickly destroys erythrocytic parasites and terminates paroxysm.  Primaquine destroys exoerythrocytic parasites.

  • Anemia or methemoglobinemia with large doses

  • Do not exceed recommended doses

  • Perform routine blood counts and hemoglobin determinations during therapy

  • Report signs of “chinconism” (tinnitis, headache, nausea, vision changes)

  • Dosages expressed in form of Primaquine base:

    • Primaquine Phosphate 26.3mg = Primaquine base 15mg

Adverse Reactions (Side Effects):

  • Gastrointestinal: nausea, vomiting, epigastric distress, cramping

  • Hematologic: leukopenia, hemolytic anmeia in patient with G-6-PD deficiency

Dosage:

  • Administered orally

  • Dosages listed in Primaquine base strength (PB)

  • Begin therapy during last two weeks of, or following a course of, suppression with Chloroquine or comparable medication

  • Malaria treatment:

    • Adult: 315mg PB every day for 14 days

    • Child: (dosed per weight): 0.3mg/kg/day PB every day for 14 days

 

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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