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Operational Medicine 2001
Danazol (Danacrine)

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Category:

  • Hormonal

Description:

  • Synthetic androgen

Indications:

  • Endometriosis

  • Fibrocystic breast disease

  • Hereditary angioedema

Contraindications:

  • Pregnancy and lactation

  • Undiagnosed vaginal bleeding

  • Markedly impaired hepatic, renal or cardiac function

Precautions:

  • Pregnancy category X

  • Rule out breast cancer prior to initiating treatment.

  • Begin endometriosis and fibrocystic breast disease therapy after ruling out pregnancy and during menstrual cycle.

  • May cause irreversible androgenic effects (hirsutism, decreased breast size, deepening of voice, clitoral hypertrophy)

Adverse Reactions (Side Effects):

  • Androgenic: acne, oily kin/hair, weight gain, mild hirsutism, decreased breast size, deepening of voice, clitoral hypertrophy, testicular hypotrophy

  • Hypoestrogenic: flushing, sweating, vaginitis, nervousness, emotional disorders

  • Hepatic dysfunction

  • CNS: dizziness, headache, sleep disorders, fatigue

  • Muscle cramps, joint pain and swelling

Dosage:

  • Administered orally

  • Mild Endometriosis: 

    • 200-400mg/day in two divided doses

  • Endometriosis: 

    • 800mg/day in two divided doses

  • Fibrocystic breast disease: 

    • 100-400mg/day in two divided doses

  • Hereditary angioedema: 

    • 200mg 2-3 times a day, decrease dose to individualized therapy

 

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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