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Operational Medicine 2001
Cefotetan (Cefotan)

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Category:

  • Antibiotic

Description:

  • Cephalosporin, Second Generation

Indications:

  • Lower respiratory tract infections (S. pneumoniae, S. aureus, H. influenzae, Klebsiella species, P. mirabilis, E. coli, Serratia marcescens)

  • Urinary tract infections (E. coli, Klebsiella species, Proteus species (including P. vulgaris, Providencia rettgeri, Morganella morganii))

  • Gynecological infections (S. aureus, S. epidermidis, Streptococcus species, S. agalactiae, E. coli, P. mirabilis, N. gonorrhoeae, Bacteriodes  species (including  B. distasonis, B. ovatus, B. thetaiotaomicron), Fusobacterium  species, gram-positive anaerobic cocci (including Peptococcus and Peptostreptococcus species))

  • Intra-abdominal infections (E. coli, Klebsiella species, Streptococcus species, Bacteriodes  species (including  B. distasonis, B. ovatus, B. thetaiotaomicron), Clostridium species)

  • Skin, bone and joint infections (E. coli, S. aureus, S. epidermidis, S. pyogenes, Streptococcus species, Klebsiella pneumonia, Peptococcus niger, Peptostreptococcus species)

Contraindications:

  • Cross sensitivity with penicillin allergies

Precautions:

  • Pregnancy category B

  • Use with caution in patients with penicillin allergy (5-10% chance of cross-reactivity)

  • Dosage modifications are generally only required in patients with severe renal impairment

Adverse Reactions (Side Effects):

  • Hypersensitivity reactions

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis

Dosage:

  • Administered by IM or IV injection

  • Adults:

    • 1-2 grams every 12 hours IM or IV for 5-10 days

  • Urinary Tract Infections:

    • 1-4 grams per day (500mg q12h, 1-2 grams q12h, or 1-2 grams q24h given IV or IM)

  • Skin infections:

    • mild to moderate: 2 grams per day (2 grams q24h IV or 1 gram q12h IV or IM)

    • severe: 4 grams per day (2 grams q12h IV)

  • Severe to life-threatening infections:

    • 4-6 grams per day (2-3 grams q12h IV)

  • Perioperative prophylaxis:

    • Pre-op: 1-2 grams IV or IM, 30 to 60 minutes pre-surgery

 

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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