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Operational Medicine 2001
Pyrimethamine and Sulfadoxine (Fansadar)

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Category:

  • Antimalarial

 Description:

  • Pyrimethamine and sulfadoxine are used together in an oral preparation to treat or prevent malaria, however, the combination is no longer recommended for malaria prophylaxis due to the possibility of fatal toxic epidermal necrolysis.  Pyrimethamine inhibits parasitic dihydrofolate reductase, and sulfadoxine antagonizes parasitic para-aminobenzoic acid, thus causing the bacteriostatic activity.  The ingredients are used together because of their synergistic activity on folic acid production.

Indications:

  • Malaria

Dosage:

Administered orally: available as tablets:   

  • pyrimethamine 25mg

  • sulfadoxine 500mg

Acute malaria, taken PO as a single dose.  Also for acute, chloroquine-resistant malarial attack, take as a single PO dose in combination with quinine

  • Adult and child >45 kg:            3 tablets

  • Child 31-45 kg:                        2 tablets

  • Child 21-30 kg:                        1½ tablets

  • Child 11-20 kg:                        1 tablet

  • Child 5-10 kg:                          ½ tablet

 

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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