Metoclopramide (Reglan)


  • Gastrointestinal


  • Prokinetic agent; antiemetic


  • Gastroesophageal reflux disease (GERD)

  • Diabetic gastroparesis

  • Facilitation of small bowel intubation

  • Not FDA approved: *slow bowel emptying, gastric stasis in preterm infants, drug-related postoperative nausea and vomiting


  • Gastrointestinal hemorrhage, mechanical obstruction, or perforation of the GI tract

  • Pheochromocytoma

  • Seizure disorders


  • Pregnancy category B; may use during pregnancy as an antiemetic

  • Avoid use during breast feeding; potent CNS effects possible

Adverse Reactions (Side Effects):

  • CNS: dizziness, drowsiness, EPS (tardive dyskinesia, akathisisa, parkinson-like symptoms, dystonia), fatigue, hallucinations, seizures, sedation, restlessness, headache

  • CV: bradycardia, hypertension, hypotension, supraventricular arrythmias

  • EENT: visual disturbances

  • GI: bowel disturbances, diarrhea, nausea

  • GU: incontinence, urinary frequency

  • HEME: agranulocytosis, leukopenia, methemoglobinemia, neutropenia, porphyria

  • METAB: amenorrhea, elevated aldosterone, gtalactorrhea, gynecomastia, impotence (hyperporlactinemia)

  • SKIN: rash, urticaria

  • MISC: neuroleptic malignant syndrome


Administered orally (tablets,syrup), IM, and IV

  • Adult: 

    • Gastroparesis/GERD: 

      • PO/IM/IV 10-15mg 30 minutes before meals and bedtime

      • PR 25mg (5 tablets compounded in polyethylene glycol) 30 minutes before meals and at bedtime.

  • Child: 

    • GERD: 

      • PO/IM/IV 0.4-0.8mg/kg/day divided into 4 doses.

    • Intubation small bowel: 

      • IV (<age 6) 0.1mg/kg; (age 6-14) 2.5-5mg

  • Renal failure adjustment: 

    • CrCl 10-50 ml/min administer 75% of recommended dose

    • CrCl <10 ml/min admister 25-50% of recommended dose




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Approved for public release; Distribution is unlimited.

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
  January 1, 2001

United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida

*This web version is provided by The Brookside Associates, LLC.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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