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Operational Medicine 2001
Mefloquine (Larium)

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Category:

  • Antimalarial

Description:

  • Quinine structural analog

Indications:

  • P. falciparum and P. vivax malaria acute treatment

  • P. falciparum and P. vivax malaria prophylaxis

  • Chloroquine-resistant malaria prophylaxis

Contraindications:

Precautions:

  • Pregnancy category C

  • Do not take on an empty stomach.

  • Drink at minimum of 240mL (8 ounces) of water with each dose.

  • Patients administered mefloquine for acute malaria attack have high relapse rate, therefore also dose with primaquine.

Adverse Reactions (Side Effects):

  • Vomiting (3%)

  • Dizziness, syncope, hallucinations, visual changes

Dosage:

  • Administered orally

  • Acute attack:

    • 5 tablets (1250mg) as a single, one time dose

  • Prophylaxis:

    • Initiate therapy one week prior to arriving in area, during stay in area and four weeks after leaving area

    • Adult: 250mg every week for 4 weeks, then 250mg every other week thereafter.

    • Children (dosing by weight):

      • 16-19kg: 62.5mg (¼ tablet)

      • 20-30kg: 125mg (½ tablet)

      • 31-45kg: 187.5mg (¾ tablet)

      • >45kg: 250mg

 

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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