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Operational Medicine 2001
Leuprolide (Lupron, Lupron Depot)

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Category:

  • Hormonal

Description:

  • Luteinizing hormone-releasing hormone (LH-RH) agonist, inhibits gonadotropin secretion

Indications:

  • Advanced prostatic cancer

  • Central precocious puberty

  • Endometriosis

  • Uterine fibroids

Contraindications:

  • Pregnancy and lactation

  • Undiagnosed vaginal bleeding

  • 30mg depot formulation is contraindicated in women

Precautions:

  • Pregnancy category X

  • Increase in occurrence of disease (prostatic and endometriosis) during initial phases of treatment.

  • May cause bone density changes

Adverse Reactions (Side Effects):

  • ECG changes and ischemia (19.4%)

  • Injection site irritation (13.8%)

  • Edema (12.2%)

  • Hot flashes and sweating (47-84%)

  • Generalized pain (6-32%)

  • Decrease in testicular size  

SubCutaneous Self-Injection Video
 5-Minute Training Video for those learning to give themselves this type of injection.
Download - CD - DVD
 www.brooksidepress.org

Dosage:

  • Administered by injection

  • Advanced prostatic cancer: 1mg SQ daily or 7.5mg IM monthly or 22.5mg IM every three months or 30mg IM every four months

  • Central precocious puberty: individualize dose per patient based on weight

  • < 25kg = 7.5mg IM every four weeks

  • 25-37.5kg = 11.25mg IM every four weeks

  • >37.5kg = 15mg IM every four weeks

  • Endometriosis: 3.75mg IM monthly or 11.25mg IM every three months

  • Uterine fibroids: recommended therapy less than 3 months

  • 3.75mg IM monthly or 11.25mg IM once for three months

 

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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