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Operational Medicine 2001
 Hydrochlorothiazide (Esidrix, HydroDiuril, Oretic)

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Category:

  • Diuruetic

Description:

  • Antihypertensive, thiazide diuretic

Indications:

  • Edema associated with CHF, hepatic cirrhosis, corticosteroid and estrogen therapy

  • Hypertension

Contraindications:

  • Anuria

  • Renal decompensation

Precautions:

  • Pregnancy category D; 1st trimester may increase risk of congenital defects; use in later trimesters does not seem to carry this risk

  • Hypokalemia, renal disease, hepatic disease, gout

  • COPD, lupus erythematosus, diabetes mellitus

  • Children, vomiting, diarrhea, hyperlipidemia

Adverse Reactions (Side Effects):

  • CNS: depression, dizziness, drowsiness, fatigue, paresthesia, weakness, headache

  • CV: irregular pulse, orthostatic hypotension, palpitations, volume depletion

  • EENT: blurred vision

  • GI: anorexia, constipation, cramps, diarrhea, nausea, pancreatitis, vomiting

  • GU: frequency, decreased libido, impotence

  • HEME: agranulocytosis, aplastic anemia, hemolytic anemia, leukopenia, neutropenia, thrombocytopenia

  • METAB: hypercalcemia, hyperglycemia, hyperuricemia, hypochloremia, hypokalemia, hypomagnesemia, hyponatremia, increased creatinine, BUN

  • SKIN: fever, photosensitivity, purpupa, rash, urticaria

 

Dosage:

Administered orally (tablet, solution)

  • Adult:   PO 12.5-50mg daily, max 200mg daily; doses >50 mg/day generally not recommended due to increased incidence of hypokalemia and other metabolic disturbances

  • Child:   PO (<6 months) 2-3.3 mg/kg/day in 2 divided doses; (>6 months) 2 mg/kg/day in 2 divided doses

Drug interactions:

  • Antidiabetics: thiazide diuretics tend to increase blood glucose, may increase dosage requirements of antidiabetic drugs

  • Digitalis glycosides: diuretic-induced hypokalemia may increase risk of digitalis toxicity

Special considerations:

  • May cause gout attacks

  • May cause sensitivity to sunlight

  • Take early in day due to increased urination

 

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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