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Operational Medicine 2001
Griseofulvin (Fulvicin P/G, Fulvicin U/F, Gris-Peg, Grisactin)

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Category:

  • Antifungal

Description:

  • Systemic antifungal

Indications:

  • Fungal infections of the skin, hair, and nails caused by susceptible organisms.

  • Antifungal spectrum usually includes: Trichophyton rubrum, T. tonsurans, T. mentagropytes, T. interdigitalis, T. verrucosum, T. megninii, T. gallinae, T. crateriform, T. sulphureum, T. schoenleinii, Microsporum audouinii, M. canis, M. gypseum, Epidermophyton floccosum

Contraindications:

  • Porphyria

  • Hepatocellular failure

Precautions:

  • Pregnancy category C; avoid use during pregnancy; use caution in nursing mothers

  • Penicillin allergy (possible cross-sensitivity)

  • Lupus erythematosus

Adverse Reactions (Side Effects):

  • CNS: dizziness, fatigue, headache, insomnia, mental confusion, paresthesias

  • GI: diarrhea, epigastric distress, BI bleeding, hepatic toxicity, nausea, oral thrush, vomiting

  • GU: menstrual irregularities, proteinuria

  • HEME: granulocytopenia, leukopenia

  • SKIN: angioneurotic edema, photosensitivity, rash, urticaria  

Dosage:

Administered orally (microsize tablets, ultramicrosize tablets, suspension)

  • Adult: (microsize) PO 500-1000mg daily in single or divided doses; (ultramicrosize) 330-375mg daily in single or divided doses, max 750mg daily

  • Child: > or = 2 years: PO (microsize) 10-15 mg/kg/day in single or divided doses; (ultramicrosize) 5.5-7.3 mg/kg/day in single or divided dose

Duration of Treatment:

Condition Duration
Tinea corporis 2-4 weeks
Tinea capitis at least 4-6 weeks
Tinea pedis 4-8 weeks
Tinea unguium 3-6 months

Drug interactions:

  • Reduces the response of : Aspirin, Cyclosporine, Oral Contraceptives, Tacrolimus, and Warfarin

  • Phenobarbital: reduces plasma griseofulvin level

Special considerations:

  • Prior to therapy, the type of fungus responsible for infection should be identified

  • Response to therapy may not be apparent for some time; complete entire course of therapy

  • Avoid prolonged exposure to sunlight

  • Clinician should be notified if sore throat or skin rash occurs

  • Store suspension at room temperature in light-resistant container

 

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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