Dextroamphetamine (Dexedrine, Dextrostat, Oxydess II, Spancap #1)


  • CNS Stimulant


  • Amphetamine derivative (DEA schedule II)


  • Narcolepsy

  • Attention deficit disorder with hyperactivitiy


  • Hyperthyroidism, hypertension, glaucoma, drug abuse

  • Cardiovascular disease, anxiety, within 14 days of taking MAOI’s


  • Pregnancy category C; excreted into breast milk

  • Tourette syndrome, child <3 years

  • (AMPHETAMINES have high abuse potential)

Adverse Reactions (Side Effects):

  • CNS: addiction, agressiveness, chills, dependence, dizziness, dysphoria, headache, hyperactivity, insomnia, irritability, restlessness, stimulation, talkativeness, tremor

  • CV: cardiomyopathy, decrease in heart rate, dysrhythmias, hypertension, palpitations, tachycardia

  • GI: anorexia, constipation, diarrhea, dry mouth, metallic taste, weight loss

  • GU: change in libido, impotence

  • SKIN: urticaria


Administered orally

  • Adult:            

    • Narcolepsy: PO 5-60mg daily in divided doses

  • Child > 12 years: 

    • Narcolepsy: PO 10mg daily increasing by 10mg once daily at weekly intervals

      • 6-12 years: PO 5mg once daily increasing by 5mg weekly (max 60mg daily)

    • Attention Deficit Disorder: 

      • Age >6 years PO 5mg 1-2 times daily increasing by 5mg a day at weekly intervals

      • age 3-6 years PO 2.5mg daily increasing by 2.5mg per day at weekly intervals (max dose 40mg daily)

  • Sustained release forms may be used for once daily dosage

Drug interactions:

  • MAOI’s: severe hypertensive reactions possible

  • Selegiline: severe hypertensive reactions possible

  • Sodium bicarbonate: may inhibit excretion of dextroamphetamine

  • Guanadrel, Guanehidine: antihypertensive effect inhibited by dextroamphetamine

Special considerations:

  • Do not crush or chew the sustained release dosage forms

  • Avoid OTC preparations unless approved by clinician


Home  ·  Military Medicine  ·  Sick Call  ·  Basic Exams  ·  Medical Procedures  ·  Lab and X-ray  ·  The Pharmacy  ·  The Library  ·  Equipment  ·  Patient Transport  ·  Medical Force Protection  ·  Operational Safety  ·  Operational Settings  ·  Special Operations  ·  Humanitarian Missions  ·  Instructions/Orders  ·  Other Agencies  ·  Video Gallery  ·  Forms  ·  Web Links  ·  Acknowledgements  ·  Help  ·  Feedback

Approved for public release; Distribution is unlimited.

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
  January 1, 2001

United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida

*This web version is provided by The Brookside Associates, LLC.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

© 2015, Brookside Associates, LLC. All rights reserved

Other Brookside Products



Advertise on this site