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Operational Medicine 2001
Captopril (Capoten)

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Category:

  • Antihypertensive

Description:

  • Angiotensin-converting enzyme (ACE) inhibitor

Indications:

  • Hypertension, heart failure, left ventricular dysfunction after MI

  • Diabetic nephropathy in Type 1 patients (proteinuria > 500mg/daily)

Contraindications:

  • Heart block

  • Bilateral renal artery stenosis

Precautions:

  • Pregnancy category C (1st trimester) and D (3rd trimester)

  • Dialysis patients, hypovolemia, leukemia, scleroderma, lupus erythematosus

  • Blood dyscrasias, thyroid disease, COPD, asthma, CHF, hyperkalemia

  • Potassium sparing diruretics, cough, aortic stenosis, pediatric use

Adverse Reactions (Side Effects):

  • CNS: chills, fever

  • CV: chest pain, hypotension, palpitations, postural hypotension, tachycardia

  • GI: loss of taste

  • GU: acute reversible renal failure, dysuria, frequency, impotence, nephrotic syndrome, oliguria, polyuria, proteinuria

  • HEME: agranulocytosis, neutropenia

  • METAB: hyperkalemia, hyponatremia

  • RESP: angioedema, bronchospasm, cough, dyspnea

  • SKIN: rash

 

Dosage:

Administered orally

  • Adult:            

    • Hypertensive crisis: PO 25mg, increasing every 2 hours until desired response; do not exceed 450mg daily

    • Hypertension: PO initial dose 12.5mg 2-3 times daily; may increase to 50mg 2-3 times daily at 1-2 week intervals; usual range 25-150mg 2-3 times daily; max 450mg daily

    • Diabetic nephropathy: PO 25mg 3 times daily

    • Congestive heart failure: PO 12.5mg 2-3 times daily; may increase to 50mg 2-3 times daily; after 14 days, may increase to 150mg 3 times daily if needed

  • Child:            

    • Hypertension: PO initiate 0.15 mg/kg/dose; double at intervals of approximately 2 hours until blood pressure controlled; max 6 mg/kg/day

Drug Interactions:

  • Allopurinol: increased risk of hypersensitivity reactions including Stevens-Johnson syndrome, skin eruptions, fever, and arthralgias

  • NSAIDS: inhibits the antihypertensive response to ACE inhibition

  • Lithium: increased risk of lithium toxicity

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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