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Operational Medicine 2001
PTT (Partial Thromboplastin Time)

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PTT detects nearly all abnormalities in clotting, due to deficiencies in clotting factors or circulating anticoagulants.

It is frequently used to monitor heparin therapy.

A modification of the test, "Activated PTT," or APTT, is basically the same as PTT, but is slightly more sensitive.

Prolonged PTT is associated with:

  • Liver disease
  • Vitamin K deficiency
  • Anticoagulant (Coumarin, Coumadin, Heparin) therapy
  • DIC
  • Hemophilia

Therapeutic Range (Heparin Therapy)

  • 2-2.5 times the normal

Normal Values*

PTT 30-45 seconds 
APTT 16-25 seconds
Therapeutic Range on oral anticoagulants 2-2.5 times normal

*These are general values taken from a variety of sources. The actual normal values may vary from lab to lab and from one type of testing protocol to another.

Approved for public release; Distribution is unlimited.

The listing of any non-Federal product in this CD is not an endorsement of the product itself, but simply an acknowledgement of the source. 

Operational Medicine 2001

Health Care in Military Settings

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

 United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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