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Creatinine Kinase (CK, CPK) is an enzyme found primarily in the heart
and skeletal muscles, and to a lesser extent in the brain. Significant
injury to any of these structures will lead to a measurable increase in CK
levels.
Elevations found in:
- Myocardial infarction
- Crushing muscular trauma
- Any cardiac or muscle disease, but not myesthenia gravis or multiple
sclerosis
- Brain injury
- Hypothyroidism
- Hypokalemia
- Once elevated, CK remains elevated for several days, if the
injury is acute.
- If there is on-going injury, the CK will remain elevated
indefinitely.
Note:
- In acute MI, CK usually rises faster than SGOT and returns to normal
faster than the SGOT.
CK/CPK Isoenzymes
There are three Isoenzymes. Measuring them is of value in the presence of
elevated levels of CK or CKP to determine the source of the elevation.
| Isoenzyme |
MM |
BB |
MB |
| Synonym |
CK3 |
CK1 |
CK2 |
| Found in: |
Skeletal M.
Heart M. |
Brain
GI Tract
GU Tract |
Heart M. |
- Normal levels of CK/CPK are almost entirely MM, from skeletal muscle.
- Elevated levels of CK/CPK resulting from acute myocardial infarction
are about half MM and half MB
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Normal Values for CK, CPK*
| Men |
5-100 IU/L |
|
Women |
10-70 IU/L |
| Pregnancy |
5-40 IU/L |
Normal Values for CK or CPK Isoenzymes*
| MM |
97%-100% |
|
MB |
0%-3% |
| BB |
0% |
*These are general values taken from a variety of
sources. The actual normal values may vary from lab to lab and from one
type of testing protocol to another.
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Approved for public release; Distribution is unlimited.
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Operational Medicine 2001
Health Care in Military Settings
Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300 |
Operational Medicine
Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
January 1, 2001 |
United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323 |
*This web version is provided by
The Brookside Associates Medical Education
Division. It contains original contents from the official US Navy
NAVMED P-5139, but has been reformatted for web access and includes advertising
and links that were not present in the original version. This web version has
not been approved by the Department of the Navy or the Department of Defense.
The presence of any advertising on these pages does not constitute an
endorsement of that product or service by either the US Department of Defense or
the Brookside Associates. The Brookside Associates is a private organization,
not affiliated with the United States Department of Defense.
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