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Military Obstetrics & Gynecology
Pharmacy

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Metaproterenol (Alupent, Metaprel)

Category:

  • Respiratory

Description:

  • Antiasthmatic, bronchodilator

Indications:

  • Bronchial asthma

  • Reversible bronchospasm

Contraindications:

  • Preexisting cardiac dysrhythmias associated with tachycardia

Precautions:

  • Pregnancy category C

  • Ischemic heart disease, cardiac dysrhythmias, hypertension, CHF

  • Hyperthyroidism, seizure disorders, diabetes mellitus, excessive use

Adverse Reactions (Side Effects):

  • CNS: anxiety, dizziness, headache, insomnia, nervousness, stimulation, tremors

  • CV: cardiac arrest, dysrhythmias, hypertension, palpitations, tachycardia

  • GI: bad taste, GI distress, nausea, vomiting

  • RESP: cough, dyspnea

  • MISC: throat irritation, muscle cramps in extremities, hypokalemia  

Dosage:

Administered orally (tablet, solution, aerosol)

  • Adult: 

    • PO 20mg 3-4 times daily

    • MDI 2-3 inhalations every 3-4 hours as needed

    • MEB 5-15 inhalations of undiluted 5% solution or 0.2-0.3ml of 5% solution diluted in 2.5-3ml normal saline every 4-6 hours (can be given more frequently if needed)

  • Child:  

    • PO (<2 years) 0.4 mg/kg/dose 3-4 times daily, in infants the dose can be given every 8-12 hours

    • PO (2-6 years) 1-2.6 mg/kg/day divided every 6-8 hours; (6-9 years) 10mg 3-4 times daily

    • NEB 0.01-0.12 ml/kg of 5% solution diluted in 2-3ml normal saline every 4-6 hours (may be given more frequently if needed)

 

 

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

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