Military Obstetrics & Gynecology
Pharmacy

Category:

• Antispasmodic, anticholinergic

Description:

• Relaxes bladder smooth muscle

Indications:

• Irritable bladder

• Urgency incontinence

Contraindications:

• Urinary retention
• Gastric retention and other severe decreased gastrointestinal motility condition
• Uncontrolled narrow-angle glaucoma and in patients who are at risk for these conditions.
•  hypersensitivity to the medication

Precautions:

• Pregnancy category B

• Used with caution in patients with hepatic or renal impairment and in patients with myasthenia gravis due to the risk of symptom aggravation.
• Bladder outflow ob-struction because of the risk of urinary retention
• Gastrointestinal obstructive disorders
• uUcerative colitis and intestinal atony.
• GI reflux
• Those taking drugs (such as bisphosphonates) that can cause or exacerbate esophagitis.

Adverse Reactions (Side Effects):

• General: abdominal pain, dry nasal and sinus mucous membranes, accidental injury, back pain, flu syndrome

• Oral: Dry mouth

• Cardiovascular: hypertension, palpitation, vasodilatation; Digestive: flatulence, GE reflux, nausea

• Musculoskeletal: arthritis

• Nervous: insomnia, nervousness, confusion

• Respiratory: upper respiratory tract infection, cough, sinusitis, bronchitis, pharyngitis

• Skin: dry skin, rash

• Urogenital: impaired urination (hesitancy), increased post void residual volume, urinary retention, cystitis.

Dosage:

Must be swallowed whole with the aid of liquids, and must not be chewed, divided, or crushed.

May be administered with or without food.

Adults:   

• 5 or 10 mg once daily at approximately the same time each day.
• Dosage may be adjusted in 5-mg increments to achieve a balance of efficacy and tolerability (up to a maximum of 30 mg/day).
• Dose adjustment may proceed at weekly intervals.